GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs11723261 | 1 | rs61792114 | chr4:289139 | ZNF718 | chr4:53272-156488:+ | 0.5 | 5.62 | 1.88E-7 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61792116 | chr4:301077 | ZNF718 | chr4:53272-156488:+ | 0.65 | 6.82 | 8.42E-10 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61794996 | chr4:209328 | ZNF718 | chr4:53272-156488:+ | 0.66 | 6.92 | 5.22E-10 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61794997 | chr4:222103 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61795001 | chr4:242057 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61795002 | chr4:242797 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61795006 | chr4:253601 | ZNF718 | chr4:53272-156488:+ | 0.53 | 5.92 | 5.01E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs61795007 | chr4:255264 | ZNF718 | chr4:53272-156488:+ | 0.53 | 5.92 | 5.01E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs61826828 | 1 | rs61826828 | chr1:174015261 | RC3H1 | chr1:173900354-173962210:- | -0.37 | -4.24 | 5.27E-5 | Schizophrenia |
| THYM | cis | rs9902453 | 1 | rs62070312 | chr17:28438877 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.23 | 5.4E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs60843830 | 1 | rs62114501 | chr2:231741 | SH3YL1 | chr2:218138-264810:- | -0.31 | -4.56 | 1.52E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs62114505 | chr2:242426 | SH3YL1 | chr2:218138-264810:- | -0.32 | -4.67 | 9.89E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs62114544 | chr2:269679 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs62114548 | chr2:274672 | SH3YL1 | chr2:218138-264810:- | -0.34 | -4.89 | 4.06E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs7246967 | 1 | rs62120832 | chr19:23064264 | ZNF492 | chr19:22817126-22850472:+ | -0.52 | -5.7 | 1.32E-7 | Bronchopulmonary dysplasia |